Tetanus: lest we forget.

Lest we forget: why the use of chemical weapons must not go unchallenged.

"Lest we forget you--methylene blue...".

Methylene blue (MB), the first synthetic drug, has a 120-year-long history of diverse applications, both in medical treatments and as a staining reagent. In recent years there was a surge of interest in MB as an antimalarial agent and as a potential treatment of neurodegenerative disorders such as Alzheimer's disease (AD), possibly through its inhibition of the aggregation of tau protein. Here ...

Lest we forget the endothelial glycocalyx in sepsis

Sepsis is the third largest cause of death in industrialised countries, but treatment remains largely supportive and effective therapeutic interventions are urgently needed. Disruption and dysfunction of the microvascular endothelium leading directly or indirectly to multiple organ failure are now recognised to underpin the pathophysiology of sepsis. Biomarkers of endothelial activation may the...

Generalized Tetanus in an Adult Patient: A Case Report

Tetanus is a neurological disorder caused by Clostridium tetani. Although vaccination has significantly reduced the incidence of tetanus worldwide, the occurrence of sporadic cases requires effective and timely treatment. In this study, we report the case of a 45-year-old man who had difficulty in swallowing and opening mouth. The patient had the history of a small puncture wound with a nail in...

Case Report Of Severe Generalized Tetanus In a 18 y/o Patient

Tetanus is a life-threatening neurologic disease caused by an infectious agent, Clostridium Tetani, and is one of the infectious diseases that is preventable by vaccination. Tetanus is characterized by painful muscle spasm and increased muscle tone, that is caused by tetanospasmin, a powerful toxin elaborated by Clostridium tetani. Due to worldwide regular vaccination, this disease rarely see...